International journal of antimicrobial agentsHumansPyrazinamideAntitubercular AgentsTuberculosisAdult
Model-informed precision pyrazinamide dosing: The establishment of a population pharmacokinetic model repository for clinical decision support.
Huan Zhang, Lu Han, Xiao-Qin Liu, Juan Wang, Yi-Lin Yun, Ming Zhou, Zheng Jiao
Published: 202610.1016/j.ijantimicag.2025.107658
Abstract
PURPOSE: Pyrazinamide (PZA) plays an important role in the treatment of tuberculosis (TB) and adequate PZA exposure is necessary to achieve optimal treatment outcomes. However, its pharmacokinetics exhibit marked interindividual variability. Such var…
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