Human pathologyHumansDNA HelicasesLung NeoplasmsTranscription FactorsMale
Detection of targetable genetic alterations in SMARCA4-deficient neoplasms of the lung - further evidence of a relationship between SMARCA4-deficient undifferentiated tumor and non-small cell carcinoma.
Danielle D'Ambrosio, Nicholas Frazzette, Matija Snuderl, George K Jour, Emily M Shaffer, Fang Zhou, Navneet Narula, Andre L Moreira, Jose G Mantilla
Published: 202610.1016/j.humpath.2025.106007
Abstract
Thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4d-UT) is an uncommon, aggressive lung neoplasm associated with smoking and characterized by loss of SMARCA4 (BRG-1) expression. Although originally considered to be a primary sarcoma, there is…
Preview only. Read the full abstract at the source