Human immunologyGastrointestinal MicrobiomeHLA-B27 AntigenAnimalsMiceHumans
HLA-B27 modulates the composition of the gut microbiota and drives a proinflammatory intestinal microecology.
Tao Zhang, Si-Yu Chen, Cong Zhang, Ruo Chen, Peng-Fei Zhou, Zhuo-Cheng Li, Qian He, Xiang-Hui Fu, Wen Wen, Cai-Peng Zhang, Mei-Yue Yao, Jie-Jie Geng
Published: 202610.1016/j.humimm.2025.111616
Abstract
The pathogenesis of autoimmune diseases such as spondyloarthritis (SpA), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD) involves genetic factors and gut microbiota dysbiosis, which have been widely reported in patients and animal mod…
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