The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia-reperfusion.
Rachel Klein, Jonathan Braat, Ashwini Arjuna, Megan Paternoster, Michael Smith, Ross Bremner, Thalachallour Mohanakumar, Davide Scozzi
Published: 202510.1016/j.healun.2025.11.030
Abstract
BACKGROUND: Primary Graft Dysfunction (PGD) is an early post-lung transplant (LTx) inflammatory condition primarily driven by lung ischemia-reperfusion injury (LIRI). Neutrophils are key mediators of LIRI, but their phenotypic diversity and maturatio…
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