GeneHumansMicroRNAsOncogene ProteinsViralPapillomavirus E7 Proteins
Innovative minicircle DNA vector encoding pri-miR-375 silences E6 and E7 oncoproteins in HPV16-positive CaSki cells.
D Pereira, A M Almeida, J A Queiroz, F Sousa, N Alves, J F A Valente, A Sousa
Published: 202610.1016/j.gene.2025.149964
Abstract
BACKGROUND: The infection by Human Papillomaviruses (HPV) has long been established as one of the main causes of cervical cancer, with HPV16/HPV18 high-risk types expressing E6/E7 oncoproteins that inhibit p53/pRB tumor suppressor proteins. Therefore…
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