Fungal biologyMycophenolic AcidPenicilliumRNA InterferenceMetabolic EngineeringMevalonic Acid
Improved production of mycophenolic acid in Penicillium brevicompactum by RNAi-mediated hmgcl gene silencing.
Yi Lin, JingJing Wang, Lin Lin, Tao Li, Yan Yan, Wei Wei, Dongzhi Wei
Published: 202510.1016/j.funbio.2025.101666
Abstract
Penicillium brevicompactum is an industrial fungus used to produce mycophenolic acid (MPA), which has a strong Mevalonate (MVA) pathway metabolic flux. However, there are currently limited genetic manipulation tools available and few reports on metab…
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