Free radical biology & medicine
UBR4 attenuates cisplatin-induced acute kidney injury by regulating the HRI-ISR axis.
Zeyu Tang, Chen Li, Cheng Yang, Xinghua Chen, Maoqing Tian, Liwen Qiao, Jiefei Zeng, Wenjing Zhen, Wei Liang, Lunzhi Liu, Huiming Wang, Xiangyou Li, Lu Zhang
Published: 202610.1016/j.freeradbiomed.2026.01.025
Abstract
Cisplatin is widely used in treating solid tumors, but its dose-limiting nephrotoxicity, which manifests as acute kidney injury (AKI), remains a major clinical challenge. The molecular pathways determining proximal tubular epithelial cell (PTEC) susc…
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