Free radical biology & medicine
The non-metabolic role of MTHFD2 in regulating mitochondrial fission-dependent mitophagy via stabilizing TOP2A mRNA in glioblastoma.
Zhuolin Du, Xingwu Liu, Yanhan Yang, Xudong Min, Jirui Wei, Yang She, Abudushalamu Abulaiti, Xiayu Jin, Zequn Su, Shizhong Zhang, Jian Liu, Karrie M Kiang, Gilberto Ka-Kit Leung, Xiaozheng He, Zhiyuan Zhu
Published: 202610.1016/j.freeradbiomed.2026.01.016
Abstract
Mitochondrial integrity is essential for tumor cell proliferation and survival. Our previous study has demonstrated the oncogenic role of the metabolic enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) in glioblastoma (GBM). Given that the no…
Preview only. Read the full abstract at the source