Free radical biology & medicine
In vivo chemogenetic generation of intraneuronal H2O2.
Dmitry I Maltsev, Maxim A Solotenkov, Ekaterina A Elesina, Alisa A Dolbeneva, Anna A Fedotova, Kseniia I Morozova, Ilya V Fedotov, Aleksandr A Lanin, Andrei B Fedotov, Dmitry A Korzhenevskii, Aleksandr A Moshchenko, Nadezda A Brazhe, Oleg V Podgorny, Vsevolod V Belousov
Published: 202610.1016/j.freeradbiomed.2026.01.006
Abstract
Recombinant D-amino acid oxidase (DAAO) is extensively employed for controlled generation of intracellular H2O2. This chemogenetic tool offers unique opportunities for dissecting the contribution of oxidative stress in the occurrence of aging-related…
Preview only. Read the full abstract at the source