Free radical biology & medicine
The Novel Nrf2 Agonist Neobavaisoflavone Attenuates Periodontitis by Inhibiting Osteoclastogenesis through Iron Homeostasis Regulation and Senescence Suppression.
Yilin Liao, Jingqiu Chen, Yaoyu Zhao, Hantao Yao, Wengwanyue Ye, Huilin Tang, Zhenru He, Yue Sheng, Shaozong Lu, Youbin Hu, Lili Jiang, Xiazhou Fu, Qi Yan, Minquan Du, Ting Li
Published: 202510.1016/j.freeradbiomed.2025.12.058
Abstract
BACKGROUND: Overactivation of osteoclasts plays a key driver of bone loss in osteolytic diseases, including periodontitis. Although current antiresorptive agents are clinically effective, their long-term safety and economic burden limit widespread us…
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