Free radical biology & medicineReactive Oxygen SpeciesMitochondriaHumansElectron Transport Complex IThiazoles
CMIT/MIT produces mitochondrial ROS via inhibiting mitochondrial complex I and II.
Donghyun Kim, Yusun Shin, Jong-In Park, Taecheol Kwak, Hangoo Kang, Haewon Kim, Youngmee Lee, Wondong Kim, Yong Joo Park, Ha Ryong Kim, Kyu Hyuck Chung, Ok-Nam Bae
Published: 202610.1016/j.freeradbiomed.2025.12.038
Abstract
A 3:1 mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one (CMIT/MIT) is an isothiazolinone biocide commonly used as preservative in various consumer products. It is also the active ingredient in humidifier disinfectant…
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