Free radical biology & medicineHumansNF-E2-Related Factor 2Kelch-Like ECH-Associated Protein 1Adenocarcinoma of LungUbiquitination
HHLA3 transcriptionally promotes GPX2 to enhance anti-oxidative capacity by attenuating KEAP1-mediated NRF2 ubiquitination in lung adenocarcinoma.
Chunting Zhang, Xiaoting Liang, Min Wang, Ke Wang, Jieyu Liu, Can Li, Yanjie Kuang, Jun Liu, Fei Zou, Liang Zhou
Published: 202610.1016/j.freeradbiomed.2025.12.030
Abstract
Lung adenocarcinoma (LUAD) is one of the most critical health challenges worldwide due to its high incidence, aggressiveness and poor prognosis. The survival strategies supporting LUAD development remain underexplored. In this study, we identified a…
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