Free radical biology & medicineAnimalsNon-alcoholic Fatty Liver DiseaseHepatocytesNLR FamilyPyrin Domain-Containing 3 Protein
PM2.5 exacerbate nonalcoholic fatty liver disease through activating hepatocytes TXNIP/NLRP3/FoxO1 signaling pathway in ob/ob mice.
Li Tian, Sibo Gao, Yao Zeng, Lisen Lin, Tianyu Li, Zhiwei Sun, Yang Yu
Published: 202610.1016/j.freeradbiomed.2025.12.027
Abstract
Growing evidence links fine particulate matter (PM2.5) exposure to nonalcoholic fatty liver disease (NAFLD), but the underlying mechanisms remain unclear. Given the critical role of hepatocyte pyroptosis in NAFLD progression, this study investigated…
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