Free radical biology & medicineAnimalsSarcoplasmic Reticulum Calcium-Transporting ATPasesMiceCalcineurinOxidation-Reduction
Redox switch C674 in SERCA2 triggers Ca2+-calcineurin-MCU-Drp1 cascade and pulmonary vascular remodeling.
Hui Chen, Yi-Xiang Qiu, Yu-Fei Xie, Xun Chen, Ying-Ying Xiang, Hai-Long Zhang, Wei-Min Yu, Ping-Ping Hu, Lang-Tao Wang, Fu-Hua Wu, Xiao-Yong Tong
Published: 202610.1016/j.freeradbiomed.2025.12.023
Abstract
Pulmonary arterial smooth muscle cell (PASMC) phenotypic switching from a contractile to a proliferative state is a central driver of pulmonary vascular remodeling in pulmonary hypertension (PH). Mitochondrial fragmentation is a key metabolic hallmar…
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