Free radical biology & medicineAnimalsNLR FamilyPyrin Domain-Containing 3 ProteinMiceInflammasomes
Forchlorfenuron exposure induces cardiotoxicity via NF-κB/NLRP3-mediated inflammasome activation independent of Septin2 inhibition.
Yana Li, Qinyu Meng, Junyao Liu, Zechun Kang, Aili Xu, Yong Xu, Meizi Yang, Haiyun Luan, Xuebo Li, Yaru Zhang, Meng Li, Yanli Cheng, Xin Xie
Published: 202610.1016/j.freeradbiomed.2025.12.021
Abstract
Forchlorfenuron (FCF), a Septin2 chemical inhibitor and widely used plant growth regulator in global agriculture, poses potential risks to human health through dietary and environmental exposure. However, the myocardial toxicity and underlying mechan…
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