Free radical biology & medicineAnimalsOxidative StressMiceHypertensionPhosphorylation
GRK4 R65L causes salt-sensitive hypertension by augmenting renal Hao2-mediated oxidative stress via increasing the phosphorylation of TPI1 and promoting H3K27ac expression.
Fuwei Zhang, Jindong Wan, Lianghong Jiang, Xiaoqian Lin, Lin Chen, Muqing Shao, Jiayao Chen, Luning Wang, Shuo Zheng, Hongmei Ren, Caiyu Chen, Pedro A Jose, Chunyu Zeng, Jian Yang
Published: 202610.1016/j.freeradbiomed.2025.12.017
Abstract
G protein-coupled receptor kinase 4 (GRK4) plays a vital role in the regulation of blood pressure. Several GRK4 gene variants have attracted attention because of their association with hypertension. However, the role of GRK4 R65L in hypertension is s…
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