Free radical biology & medicinealpha 1-AntitrypsinHumansNicotianaRecombinant Fusion ProteinsCell-Free System
Rapid design and production of Alpha-1 antitrypsin fusion proteins in a plant-based cell-free expression system.
Anindya Karmaker, Faris Alyami, Connor A Randolph, Saee Ranade, Yiyun Liu, Anugraha Thyagatur, Justin Wong, Paulo A Zaini, Charles Williams, Abhaya M Dandekar, Carroll E Cross, Roland Faller, Carlito B Lebrilla, Alison A McCormick, Somen Nandi
Published: 202610.1016/j.freeradbiomed.2025.12.012
Abstract
Alpha-1 antitrypsin deficiency (AATD) is a rare disease, causing significant lung damage, that is currently treated with FDA approved replacement therapy comprised of weekly infusions of costly plasma-derived AAT. Fusing AAT with a crystallizable fra…
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