Free radical biology & medicineCurcuminNF-E2-Related Factor 2RatsNeuroprotective AgentsPC12 Cells
Identification and mechanistic exploration of a mono-carbonyl analog A1 of dietary curcumin as a potent Nrf2-dependent neuroprotective agent within a cellular model of Parkinson's disease.
Yu Zhang, Dong Lin, Xiaojun Yao, Fang Dai, Qi Wang, Bo Zhou
Published: 202610.1016/j.freeradbiomed.2025.12.007
Abstract
Oxidative stress exerts a considerable influence on the advancement of Parkinson's disease (PD). Hence, the creation of novel neuroprotective agents based on the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) and inspired by dietary…
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