Free radical biology & medicineAnimalsMiceIschemic StrokeHumansGTP Phosphohydrolases
Decreased OPA1 expression increases neuronal vulnerability to ischaemic stroke during ageing: Role of Timm8b as a therapeutic target.
Hang Li, Xiang Li, Zhongmou Xu, Lianxin Li, Eryi Sun, Chang Cao, Jinxin Lu, Lei Bai, Gang Chen, Qing Sun, Haiying Li
Published: 202610.1016/j.freeradbiomed.2025.12.005
Abstract
Ischaemic stroke stands as a major global driver of mortality and disability, with advancing age significantly worsening patient outcomes. Mitochondrial impairment plays a pivotal role in both ischaemia-triggered neuronal damage and ageing, yet its p…
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