Free radical biology & medicineAnimalsAquaporin 4Toll-Like Receptor 4MiceMesenchymal Stem Cells
Aquaporin-4-overexpressing mesenchymal stem cells promote neurological recovery after intracerebral hemorrhage by inhibiting TLR4/NF-κB signaling.
Yilu Li, Wenhui Yang, Yushi Tang, Zhenxing Tao, Pengpeng Li, Bai Xu, Xudong Zhao, Xiaojie Lu
Published: 202610.1016/j.freeradbiomed.2025.12.004
Abstract
Intracerebral hemorrhage (ICH), a condition characterized by non-traumatic bleeding in the brain parenchyma, leads to acute neurological deficits through direct tissue injury and neuroinflammation, yet effective therapeutic strategies remain limited.…
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