Free radical biology & medicineOmeprazoleHydrogen SulfideSulfidesOxidation-ReductionSulfur
Hydrogen sulfide reduces omeprazole and is oxidized to polysulfides and elemental sulfur.
Janina Lenzi-Camisa, Dayana Benchoam, Jenner Bonanata, Mauricio Mastrogiovanni, Ricardo Faccio, Matías N Möller, Beatriz Alvarez
Published: 202610.1016/j.freeradbiomed.2025.11.059
Abstract
Omeprazole is a medically used proton pump inhibitor. It covalently modifies the H+,K+-ATPase responsible for acid production in the stomach. Omeprazole itself is an inactive sulfoxide. At acidic pH, it produces a sulfenic acid derivative in equilibr…
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