Free radical biology & medicineAnimalsNLR FamilyPyrin Domain-Containing 3 ProteinMiceHSP90 Heat-Shock Proteins
HSP90α facilitates the dephosphorylation of DRP1 at the Ser637 residue, thereby promoting NLRP3 inflammasome activation and exacerbating brain injury in sepsis.
Haitao Yang, Xinyu Zhou, Baihao Zhang, Yuzhen Shan, Yichen Jin, Enzhuang Pan, Dong Xu, Liwen Fan, Panpan Zhao, Yong Sun, Jingquan Dong
Published: 202610.1016/j.freeradbiomed.2025.11.056
Abstract
Sepsis-associated encephalopathy (SAE) is a common and serious complication of sepsis, characterized by neuroinflammation and cognitive dysfunction, yet its molecular mechanisms remain unclear. This study aimed to investigate the role of heat shock p…
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