Free radical biology & medicineAnimalsNF-E2-Related Factor 2NADPH Oxidase 4CardiotoxicityDoxorubicin
Bergapten mitigates doxorubicin-induced cardiotoxicity via NOX4/Nrf2/HO-1 axis: Insights from in vitro and in vivo models.
Bijoy Krishna Banik, Sourav Kundu, Swati Tirunal Achary, Bedilipi Das, Shobhit Verma, Madhav Nilakanth Mugale, Bidya Dhar Sahu
Published: 202610.1016/j.freeradbiomed.2025.11.055
Abstract
Doxorubicin (DOX) is a frequently recommended chemotherapeutic agent. The dose-dependent and cumulative cardiotoxicity of DOX prevents its therapeutic use despite its clinical efficacy. Bergapten (BeG) is a naturally occurring furanocoumarin found in…
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