Free radical biology & medicineGastrointestinal MicrobiomeAnimalsMiceProto-Oncogene Proteins c-aktReactive Oxygen Species
Gut microbial metabolite alleviates osteoporosis by attenuating AKT-NFATc1 signaling pathway and ROS production.
Jinwu Bai, Gengyu Han, Jixing Fan, Ruideng Wang, Shilong Su, Ao Sun, Daole Hu, Yang Lv, Shan Gao, Fang Zhou
Published: 202610.1016/j.freeradbiomed.2025.11.054
Abstract
Postmenopausal osteoporosis is a prevalent bone disorder characterized by an imbalance in bone homeostasis following estrogen decline, which leads to progressive bone loss. Research has shown that estrogen deprivation-induced osteoporosis (OVX) is pa…
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