Free radical biology & medicineMaleAnimalsMitochondriaOxidative StressHumans
Trimethylamine-N-oxide disrupts spermatogenesis by inducing mitochondrial oxidative stress injury through Hippo signaling.
Shuo Wang, Gongchao Ma, Cancan Qi, Shilong Cheng, Houhua Lai, Lepeng Zhou, Guangyan Wu, Zhongjie Chen, Xiangming Mao, Tao Jing, Yan He, Hongwei Zhou
Published: 202610.1016/j.freeradbiomed.2025.11.052
Abstract
BACKGROUND: The gut-testis axis is increasingly recognized as a regulator of male reproductive health; however, the key microbial contributors, metabolites, and underlying mechanisms remain unclear. METHODS: We performed fecal metagenomic sequencing…
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