Free radical biology & medicineAnimalsFerroptosisAcetaminophenMiceHypoxia-Inducible Factor-Proline Dioxygenases
An intrabody targeting PHD2 protects mice against acetaminophen-induced liver injury by attenuating ferroptosis.
Ze Ren, Ying Wang, Cheng Cheng, Yingming Zhang, Yanfei Liu, Yuchong Wei, Zhaoyang Liu, Jingyue Zhang, Zijian Shi, Jiayin Yu, Wanning Hu, Junbo Ye, Jianxia Wang, Siyu Qiu, Guiying Li
Published: 202610.1016/j.freeradbiomed.2025.11.050
Abstract
Acetaminophen (APAP) overdose has become the most common cause of acute liver failure. Ferroptosis plays a critical role in APAP-induced liver injury (AILI). Although inhibiting prolyl hydroxylase 2 (PHD2)-mediated degradation of hypoxia-inducible fa…
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