Free radical biology & medicineHumansNF-E2-Related Factor 2MicrogliaAutophagyOleanolic Acid
NRF2 activation by CDDO-Im regulates inflammatory and autophagy pathways in human microglial cells.
Ching-Tung Chu, Akira Uruno, Takafumi Suzuki, Keiko Taguchi, Liam Baird, Fumiki Katsuoka, Masayuki Yamamoto
Published: 202610.1016/j.freeradbiomed.2025.11.046
Abstract
Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles, accompanied by elevated oxidative stress and inflammation. Microglia, the resident macrophages in the brain, play a key protective role by clearing pl…
Preview only. Read the full abstract at the source