Free radical biology & medicineNF-E2-Related Factor 2AnimalsMitophagyMitochondriaUbiquitin-Protein Ligases
APOE4 impairs Nrf2-PINK1/Parkin-dependent mitochondrial clearance through disrupted antioxidant and mitophagy signaling.
Firoz Akhter, Asma Akhter, Donghui Zhu
Published: 202610.1016/j.freeradbiomed.2025.11.040
Abstract
APOE4, the strongest genetic risk factor for sporadic Alzheimer's disease (AD), is closely associated with mitochondrial dysfunction, yet the mechanisms remain poorly defined. We identify a previously unrecognized failure of the Nrf2-PINK1/Parkin axi…
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