Free radical biology & medicineFemaleHumansTumor Suppressor Protein p53Fallopian TubesGlutathione Transferase
Mutant p53 disrupts antioxidant defense in fallopian tube epithelium via GSTAs suppression: A pathway to serous tubal carcinogenesis.
Destiny B Burnett, Sandy St-Hilaire, Leah Dodds, Omar Nelson, Jovanka Ravix, Ramlogan Sowamber, Ashlee J Sealy, Iru Paudel, Osmaray Morales, Xiang-Xi Xu, Matthew Schlumbrecht, Patricia A Shaw, Elizabeth R Smith, Sophia H L George
Published: 202610.1016/j.freeradbiomed.2025.11.027
Abstract
High grade serous ovarian cancer (HGSOC) is the most common and aggressive type of epithelial ovarian cancer. The fimbria of the fallopian tube is the likely site of origin based on the presence of distinct precancerous lesions with TP53 signatures k…
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