Free radical biology & medicineAmyloid Precursor Protein SecretasesHumansAnimalsMiceAspartic Acid Endopeptidases
Endothelial BACE1, regulating the endothelial-to-mesenchymal transition (EndMT) induced by particulate matter (PM), is associated with cerebrovascular disease: Involvement of endothelial BACE1 in BBB disruption caused by diabetes.
Jung Hyun Park, Ji-Young Choi, Geun-Young Kim, Minkyeong Kim, Sung-Hye Park, Young Ho Koh
Published: 202610.1016/j.freeradbiomed.2025.11.021
Abstract
EndMT has emerged as a mechanism of vascular disease onset. Our previous study showed that PM exposure induces EndMT-associated cardiac fibrosis and BACE1-mediated brain endothelial dysfunction. Here we investigated whether BACE1 and EndMT are associ…
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