Free radical biology & medicineAnimalsOsteoporosisNanoparticlesMicePolylactic Acid-Polyglycolic Acid Copolymer
Precision targeting of METTL3 via bone-homing bisphosphonate-modified PLGA nanoparticles mitigates osteoporotic bone loss through m6A-PPARα crosstalk in ferroptotic regulation.
Qing An, Yi Xie, Chang Xu, Qun Xu, Fanshuang Kong
Published: 202610.1016/j.freeradbiomed.2025.11.012
Abstract
Osteoporosis (OP), characterized by progressive bone loss, is closely linked to ferroptosis-induced senescence of bone marrow mesenchymal stem cells (BMSCs). N6-methyladenosine (m6A) modification of peroxisome proliferator-activated receptor alpha (P…
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