Free radical biology & medicineAnimalsCell ProliferationPulmonary ArteryHypertensionPulmonary
TRIB2 promotes pulmonary artery smooth muscle cell proliferation through SERCA2 ubiquitination in pulmonary hypertension.
Wenkang Zhang, Minhao Zhang, Ziqi Sha, Yuyu Yao, Yuhan Qin, Yong Qiao, Dong Wang, Chengchun Tang, Gaoliang Yan, Mingkang Li
Published: 202610.1016/j.freeradbiomed.2025.11.009
Abstract
Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling (PVR) driven by the hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). This study investigated the role of tribbles homolog 2 (TRIB2), a pseudokinase prot…
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