Free radical biology & medicineEugenolFerroptosisNF-E2-Related Factor 2AnimalsNucleus Pulposus
Eugenol attenuates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the Nrf2/GPX4 pathway.
Shuai Sun, Xun Lu, Shu Yang, Haibo Liang, Gan Lyu, Yuli Chen, Lianggao Yu, Zhan Gao, Jiale Wang, Peng Xiao, Lintong Jin, Chongan Huang, Xiangyang Wang
Published: 202610.1016/j.freeradbiomed.2025.11.006
Abstract
Low back pain (LBP), recognized as a prevalent musculoskeletal disorder imposing considerable socioeconomic burdens, primarily stems from intervertebral disc (IVD) degeneration. Progressive death of nucleus pulposus (NP) cells, coupled with the forma…
Preview only. Read the full abstract at the source