Free radical biology & medicineMitophagyAnimalsFerroptosisMiceHumans
Cepharanthine-induced mitophagy through regulation of FBXL4-BNIP3 drives ferroptosis leading to robust anti-lung cancer efficacy.
Liu-Gen Li, Yong-Hong Xu, Ning Han, Fan Leng, Jun Hu, Hua-Zhen Xu, Hongyao Huang, Tong-Fei Li, Xiao Chen
Published: 202610.1016/j.freeradbiomed.2025.10.302
Abstract
Cepharanthine (Cep), a natural alkaloid from Stephania (Menispermaceae), exhibits broad-spectrum anti-cancer activity. In the present study, Cep was found to induce ferroptosis and mitophagy, for which the relationship and upstream targets remain une…
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