Free radical biology & medicineAnimalsNF-E2-Related Factor 2PPAR alphaHumansRats
Dual-PPARα/δ agonist H11 alleviates tendinopathy via modulating the Nrf2/HO-1/GPX4 pathway.
Yang Lu, Shaojie Yang, Huan Liu, Yibo Zhang, Zhizhuo Li, Jun Lu, Qing Jiang, Xingquan Xu
Published: 202610.1016/j.freeradbiomed.2025.10.301
Abstract
Tendinopathy, a prevalent degenerative musculoskeletal disorder, remains a therapeutic challenge due to limited efficacy of existing treatments. Oxidative stress and ferroptosis are pivotal pathological mechanisms in tendinopathy, which are linked to…
Preview only. Read the full abstract at the source