Free radical biology & medicineFerroptosisAnimalsIron OverloadHumansMice
REL/STEAP4 promotes aortic valve calcification by inducing iron overload and ferroptosis in valvular interstitial cells.
Ruikang Guo, Bingchuan Geng, Wai Yen Yim, Peng Zhu, Hongyan Zhang, Tixiusi Xiong, Yu Feng, Jiawei Shi, Nianguo Dong, Jiangyang Chi
Published: 202610.1016/j.freeradbiomed.2025.10.269
Abstract
Ferroptosis has been recognized to be pivotal in the pathogenesis of various cardiovascular diseases, yet with poor understanding regarding its involvement in calcific aortic valve disease (CAVD). This study established a connection between iron over…
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