Free radical biology & medicineAnimalsOxidative StressAutophagyMiceDepression
P2Y6 receptor blockade promotes depression-like symptoms through oxidative stress and impaired autophagy.
Yue Hu, Qichao Gong, Xiaoli Jia, Qiuyan Zhu, Chengyou Zheng, Tahir Ali, Shupeng Li, Rui Liang, Jinxing Feng
Published: 202610.1016/j.freeradbiomed.2025.10.268
Abstract
The P2Y6 receptor (P2Y6R) is implicated in neuroinflammation and synaptic plasticity, but its role in depression remains unclear. This study reveals a crucial role for the P2Y6 receptor (P2Y6R) in depression. Using a chronic restraint stress (CRS) mo…
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