Free radical biology & medicineTRPM Cation ChannelsAnimalsRenal InsufficiencyChronicMice
Genetic deletion of TRPM8 channels restores microvascular function and mitigates chronic kidney disease progression.
Jenq-Wen Huang, Chia-Hui Chen, Ming-Tsun Tsai, Po-An Hu, Bei-Chia Guo, Wen-Hua Chen, Hao-Wen Chen, Tzong-Shyuan Lee, Der-Cherng Tarng
Published: 202510.1016/j.freeradbiomed.2025.10.252
Abstract
Chronic kidney disease (CKD) is a key public health issue. It initiates an inflammatory response and fibrotic processes, resulting in a gradual decline in kidney function. Yet, the detailed mechanism underlying the pathogenesis of chronic kidney dise…
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