Free radical biology & medicineAnimalsOxidative StressCataractEpithelial CellsRats
Transcription factor EGR2 drives cataract formation through IGFBP3-mediated oxidative injury in lens epithelial cells.
Wanqian Li, Yue Zou, Wanqiu Zheng, Jiaojiao Zhang, Chao Cen, Ruonan Li, Hong Cheng, Shengping Hou, Wenjuan Wan, Liang Liang, Juan Kang, Shijie Zheng, Ke Hu
Published: 202510.1016/j.freeradbiomed.2025.10.009
Abstract
Cataracts, a prevalent ocular disorder, represent the leading cause of global blindness. Evidence indicates that oxidative stress-induced lens epithelial cells (LECs) apoptosis constitutes a key pathogenic mechanism in age-related cataract (ARC). Alt…
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