Free radical biology & medicineAnimalsHumansMiceAldehyde DehydrogenasePulmonary Emphysema
Aldehyde dehydrogenase ALDH3A1 rescues cigarette smoke-induced emphysema by conferring alveolar type 2 to type 1 cell transition.
Jiajing Cui, Shuai Han, Jiachen Li, Xiaobo Li, Lirong Liang
Published: 202510.1016/j.freeradbiomed.2025.10.002
Abstract
Cigarette smoke (CS) is one of the major risk factors of emphysema, which is characterized by alveolar destruction. Alveolar type 2 (AT2) cells enable regeneration of alveoli after injury by transiting into alveolar type 1 (AT1) cells; however, the m…
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