Free radical biology & medicineAnimalsPyroptosisMiceOsteoarthritisNF-E2-Related Factor 2
MOTS-c attenuates mitochondrial dysfunction induces pyroptosis and cartilage degradation in osteoarthritis via an Nrf2-Dependent Mechanism.
Kechi Li, Tao Yang, Feiyu Chen, Chao Lou, Yanlin Chen, Zhenzhong Chen, Lin Ye, Xiaolong Sun, Guoxiang Liu, Chenglong Xie, Jiawei Fang, Xingyu Hu, Ye Zhu, Bin Liu, Dengwei He
Published: 202510.1016/j.freeradbiomed.2025.09.056
Abstract
Osteoarthritis, a common chronic degenerative disease in the field of orthopedics, is caused by the interaction of mechanical stress, traumatic inflammation, and metabolic imbalance, and this interaction progresses over time. MOTS-c, a mitochondria-d…
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