Food research international (Ottawa, Ont.)Molecular Docking SimulationAnimalsTestosteroneCalcium ChannelsT-Type
Rational discovery of testosterone-enhancing peptide (AGNYGLPT) from sea cucumber: targeting T-type calcium channels through docking, molecular dynamics simulations, and cellular validation.
Xianliang Luo, Tengyue Liu, Liping Xu, Qiao Guan, Baodong Zheng, Yafeng Zheng, Wangxin Liu
Published: 202610.1016/j.foodres.2025.118078
Abstract
Calcium ions (Ca2+) are a crucial signaling factor in testosterone synthesis. This study employed computer-guided peptide screening and mechanism exploration to elucidate how sea cucumber peptide (SCP) promotes testosterone synthesis via Cacna1g (T-t…
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