Rational design of an engineered zearalenone lactone hydrolase with enhanced thermostability and acid tolerance for zearalenone degradation in food.

Zearalenone (ZEN), a prevalent and stable Fusarium mycotoxin in cereals, threatens food safety and resists conventional processing. Natural ZEN hydrolases are often inadequate under industrial thermal and acidic conditions. Here, we engineered a robu…

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