Food chemistryCoumaric AcidsHumansTasteMolecular Docking SimulationMolecular Structure
Structural modification of ferulic acid for manipulating its bitterness inhibition regulation.
Lu Sun, Zichao Fang, Junhan Zhou, Huanyu Yang, Hassan Muzaffar, Jianxian Zheng, Zhongkai Zhou
Published: 202510.1016/j.foodchem.2025.146994
Abstract
This study identified 9 derivatives of ferulic acid via in silico screening, aiming to explore the effect of molecular structure on bitterness inhibition. Their HepG2 cell LC50 values ranged from 0 to 1.65 mg/mL.The electronic tongue test results ind…
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