Food and chemical toxicology : an international journal published for the British Industrial Biological Research AssociationAnimalsAcetaminophenMaleGlutathioneMice
Differential effects on acetaminophen-induced nephrotoxicity and liver injury following modulation of glutathione resynthesis.
Yasaman Etemadi, Jephte Y Akakpo, Timothy A Fields, Anup Ramachandran, Hartmut Jaeschke
Published: 202610.1016/j.fct.2025.115896
Abstract
Acetaminophen (APAP) overdose is a leading cause of acute liver failure (ALF), with acute kidney injury (AKI) increasing morbidity and mortality. N-acetylcysteine (NAC) prevents APAP-induced liver damage, but not AKI, highlighting the need to address…
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