Food and chemical toxicology : an international journal published for the British Industrial Biological Research AssociationHumansInsecticidesEpithelial CellsIntestinal MucosaAnimals
Hazard assessment of insecticidal proteins representing different structural classes using an in vitro experimental platform of human intestinal epithelial monolayers.
Cindi S Zimmermann, Sujatha Rajeev Thundivalappil, Brittany Wilson-Mifsud, Sydney Boyle, Yiwei Wang, Ian Lamb, Matthew Merrell, Carey A Mathesius, Melissa N Fallers, JoAnna Bultman, Brenda L Smith, Anne B Carlson, Katie L Stewart, Mark Nelson, Bryan P Hurley
Published: 202610.1016/j.fct.2025.115850
Abstract
Hazard assessment of proteins using human-derived intestinal epithelial cell (IEC) lines has been investigated previously. The purpose of this work was to a) reduce occurrences of false positives by including a non-hazardous protein (BSA) negative co…
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