Food and chemical toxicology : an international journal published for the British Industrial Biological Research AssociationAnimalsOxidative StressMaleRatsSprague-Dawley
The synthetic cannabinoid CUMYL-4CN-BINACA induces hepatic injury in rats via oxidative stress, NF-κB activation, Nrf2 suppression, EDEM-1, ER stress-mediated apoptotic pathways.
Tuba Dogan, Ozkan Aksakal, Omercan Alat, Mesut Bünyami Halici, Cihan Gur
Published: 202610.1016/j.fct.2025.115809
Abstract
Synthetic cannabinoids (SCs), particularly CUMYL-4CN-BINACA (C-4CN-B), are highly potent psychoactive substances linked to systemic toxicity, including liver injury. This study evaluated the dose-dependent hepatotoxic effects of C-4CN-B and the under…
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