Experimental neurology
Abnormal upregulation of SPP1 promotes fibrotic scar after peripheral nerve repair (FS-PNR) by driving M2 macrophage polarization.
Jingyuan Fan, Zhe Li, Nan Zhang, Shuolin Wang, Canbin Zheng, Qingtang Zhu, Honggang Wang, Jian Qi, Liwei Yan
Published: 202510.1016/j.expneurol.2025.115612
Abstract
Fibrotic scar after peripheral nerve repair (FS-PNR) hinder axon regeneration and functional recovery. However, the mechanism underlying FS-PNR formation remains elusive. SPP1, a glycoprotein known to promote fibrosis in multiple organ systems, was a…
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