Experimental neurologyAnimalsAlzheimer DiseaseRatsHMGB1 ProteinAluminum Chloride
HMGB1 Box A gene therapy reverses cognitive and neuropathological features in AlCl₃/D-galactose rat model of Alzheimer's disease.
Suangsuda Supasai, Pakawat Suntaratti, Mingkwan Odton, Tasneem Longji, Thararat Karananan, Sakawdaurn Yasom, Sumate Ampawong, Yanin Limpanont, Apiwat Mutirangura
Published: 202610.1016/j.expneurol.2025.115583
Abstract
Alzheimer's disease (AD), the leading cause of dementia, is pathologically defined by the accumulation of amyloid-β and tau pathology, resulting in progressive cognitive decline. Our previous work demonstrated that high mobility group box 1 (HMGB1) B…
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