Experimental neurologyAnimalsHippocampusMiceKnockoutAttention Deficit Disorder with Hyperactivity
Lgi2-deficient mice manifest epileptiform activity in the developing hippocampal network and ADHD-like behavioural comorbidity in adulthood.
Tiina Savonlehto, Elisa Nevalainen, Tiina-Kaisa Kukko-Lukjanov, Marjo K Hytönen, Eija Seppälä, Mikael Segerstråle, Juha Partanen, Sari E Lauri, Hannes Lohi, Tomi Taira
Published: 202610.1016/j.expneurol.2025.115541
Abstract
Genetic variants affecting brain development can lead to an increased risk of neurological disorders later in life. A protein-truncating variant in a gene for secreted neural protein LGI2 (Leucine-rich glioma-inactivated 2) is associated with remitti…
Preview only. Read the full abstract at the source